Cathepsin K anticorps (AA 163-274)

N° du produit ABIN6654328

L’anticorps Souris Monoclonal anti-Cathepsin K a été validé pour IHC (p). Il convient pour détecter Cathepsin K dans des échantillons de Humain.

Aperçu rapide pour Cathepsin K anticorps (AA 163-274) (ABIN6654328)

Antigène: Cathepsin K (CTSK)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin K est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTSK-2791

Détail du produit anti-Cathepsin K anticorps

Épitope: AA 163-274

Purification: Purified

Pureté: Protein G affinity chromatography

Immunogène: A portion of amino acids 163-274 from the human protein was used as the immunogen for the Cathepsin K antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Cathepsin K antibody to be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Cathepsin K antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur Cathepsin K

Antigène: Cathepsin K (CTSK)

Autre désignation: Cathepsin K / CTSK

Sujet: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades